BRCA1 and breast cancer: As multiple recognized BC genes such as BRCA1 (also known as FANCS), BRCA2 (FANCD1), and PALB2 (FANCN) all form part of both the FA pathway and the HRR machinery needed for double-stranded DNA repair, various studies investigated the role of other FA genes such as FANCD2 with regards to cancer susceptibility, and more specifically BC [45].