TP53 and myelodysplastic syndrome: Studies have found that the incidence of chromothripsis ranged from 0 to 10.5% in patients with MDS, and chromothripsis was detected in 8 of 13 (61.5%) patients with TP53 mutations, including 13 of 13 (100%) with complex karyotypes [10, 16, 17, 25].