HK2 and type 2 diabetes mellitus: Roxadustat exposure led to induction of HIF target gene mRNAs for GLUT1 (Fig. 2a), HK2 (encoding hexokinase 2) (Fig. 2c), MCT4 (encoding monocarboxylate transporter 4) (Fig. 2j) and HIF-P4H-2 (also known as PHD2 or EGLN1) (Fig. 2l) in myotubes from donors with NGT, with a blunted response in myotubes from donors with type 2 diabetes (Fig. 2a, j, l).