Exposure to roxadustat led to a reduction in insulin-stimulated phosphorylation of Akt-Ser473 and GSK3β-Ser9, and an increase in insulin-stimulated phosphorylation of AS160-Thr642 in myotubes from donors with type 2 diabetes (Fig. 5a–d). Here, TBC1D4 is linked to type 2 diabetes mellitus.