LDHA and type 2 diabetes mellitus: HIF target gene mRNAs for LDHA (encoding lactate dehydrogenase A) (Fig. 2e), PDK1 (encoding pyruvate dehydrogenase kinase isoform 1) (Fig. 2f) and GBE1 (encoding glycogen-branching enzyme 1) (Fig. 2g) were induced similarly in response to roxadustat in myotubes when comparing the NGT and type 2 diabetes groups.