IGHE and epilepsy: ClinVar gives no further information for G251D; however, the G251S mutation is linked with DEE19 (developmental and epileptic encephalopathy, 19), ECA4 (epilepsy, childhood absence 4), EIG13 (epilepsy, idiopathic generalized, susceptibility to, 13), and IGE (idiopathic generalized epilepsy) (https://www.ncbi.nlm.nih.gov/clinvar/).