EZH2 and Down syndrome: Moreover, given that mutations in EED, EZH2, and SUZ12 have all been associated with overgrowth and a range of co-morbidities in Cohen-Gibson, Weaver, and Imagawa-Matsumoto syndrome patients (Cohen and Gibson, 2016; Tatton-Brown et al., 2011; Cooney et al., 2017; Imagawa et al., 2017; Tatton-Brown et al., 2013), and similar outcomes have been observed in mouse offspring lacking EED in oocytes (Prokopuk et al., 2018), further work may provide insights into these rare human conditions.