Time-course scRNA-seq analysis of ASCL1+ SCLC cultured in vitro demonstrated the ability of MYC to promote SCLC subtype evolution, indicating that the SCLC-A, SCLC-N and SCLC-Y subtypes might represent different stages of SCLC progression (Ireland et al., 2020). The gene discussed is MYC; the disease is small cell lung carcinoma.