CD8A and atherosclerosis: Conversely, Clement et al46 also found that introducing a point mutation (D227K) into Qa1 (a TFH-expressed nonclassical MHCI molecule) to block the function of Qa1-restricted CD8+ TREGs in Apoe–/– mouse model led to increased atherosclerosis due to TFH accumulation, but whether these were fully differentiated TFH cells was not assessed.