Global IL-4 deletion led to reduced atherosclerosis and decreased oxLDL-specific IgG1 antibodies.84 TH2-derived IL-5 production was also associated with increased secretion of natural T15/E06 IgM from B1 cells.85 Thus, hematopoietic IL-5 deficiency in Ldlr–/– mice led to increased atherosclerosis. The gene discussed is LDLR; the disease is atherosclerosis.