Moreover, recent work from Clatworthy and Mallat laboratories showed that low-dose IL-2 treatment in patients with acute coronary syndrome promoted the generation of IL-10–producing B cells.92 Therefore, the role of IL-2 in T-cell/B-cell interactions during atherosclerosis merits further investigation given the potential of using low-dose IL-2 therapy for cardiovascular disease. The gene discussed is IL2; the disease is atherosclerosis.