TFH cells have not been identified within plaques51 but can be found, along with GCs and MZB cells, in ATLOs, which form within the adventitia in advanced atherosclerosis.52 TFH cells have been detected in increased numbers in ATLOs from patients with abdominal aortic aneurysm46 (especially TFH1)53 and in aged Apoe–/– mice. The gene discussed is APOE; the disease is atherosclerosis.