CD40LG and coronary artery disorder: This is largely attributed to oxidation-specific epitope (OSE)–binding IgM antibodies that reduce inflammation within plaques by clearing apoptotic cells26,27 and neutralizing oxidized low-density lipoprotein (oxLDL) uptake.28 Reflecting this, several clinical studies indicate that oxLDL-specific IgM titers29 and even circulating MZB-like cell frequencies30 in patient blood inversely correlate with coronary artery disease severity while no consistent correlation has been reported with oxLDL-specific IgG.