Mice with BAFF-R deletion display significantly better LV function post-MI compared with controls.10 This effect is, in part, mediated through reduced numbers of B2 cells and a reduction in B2 cell–derived CCL7, which limits Ly6Chi monocyte infiltration in the ischemic heart and improves cardiac remodeling post-MI.10 The gene discussed is CCL7; the disease is myocardial infarction.