SESN2 and polycystic ovary syndrome: The serum sestrin 2 values of the obese PCOS group were statistically significantly lower than the women in the nonobese PCOS and control groups (p = 0.001, p = 0.0001), while the sestrin 2 values of the nonobese PCOS group were statistically significantly lower than the women in the control group (p = 0.0001).