A statistically significant difference was observed between the serum TRB3 values of the women in the obese PCOS (781.22 ± 476.75 pg/mL), non-obese PCOS (583.31 ± 362.46 pg/mL) and control groups (228.49 ± 170.76 pg/mL) (p = 0.0001). The gene discussed is TRIB3; the disease is polycystic ovary syndrome.