Besides the anti-inflammatory and antioxidant properties, IOP has also been found to induce apoptotic cell death in treated human lung cancer cells (LLC1 and A549 cell lines) through liver kinase B1 (LKB1) activation of adenosine monophosphate-activated protein kinase (AMPK) and reduction of mitochondrial membrane potential (MMP) (Jiang et al. 2020). Here, STK11 is linked to lung cancer.