AKT1 and Hepatic fibrosis: Another compound isolated from I. obliquus, inonotsuoxide B (22), was found to possess anti-fibrotic activity as they suppressed protein expression of α-smooth muscle actin (α-SMA) and type I collagen, reduced α-SMA mRNA expression induced by platelet-derived growth factor-BB (PDGF-BB), and activated the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and extracellular signal-regulated kinase (ERK) signalling pathways, thus inhibiting the viability and activation of PDGF-BB-stimulated hepatic stellate cells (HSC-T6) to protect against hepatic fibrosis (Jin et al. 2022).