As to how countering effects of elevated MAO-A protein could have longer lasting benefit, preventing monoamine deficits could be helpful since monoamine depletion, whether by reduction of serotonin precursor tryptophan,8 inhibition of tyrosine hydroxylase through administration of α-methyl-p-tyrosine9 or removal of all three by disruption of vesicular storage via reserpine10 leads to depressive syndromes, with the latter occurring after substantial time delay. Here, MAOA is linked to depressive disorder.