Based on our further exploration of cellular communication, we concluded that epithelial cells mainly bound to receptors such as EPHA2, IL6ST, ERBB3, BMPR2, EGFR and MET and participated in cancer cell proliferation, apoptosis and differentiation through the Hippo, ErbB, PI3K-Akt and Ras signalling pathways. The gene discussed is ERBB3; the disease is cancer.