Since smoking and alcohol drinking may affect the level of pyroptosis-related cytokines in lung cancer patients, we further divided lung patients into smoking and non-smoking groups, or drinking and non-drinking groups, and then compared the levels of TNF-α, IFN-γ, IP-10, MIP-1α, MIP-1β and MIP-2 in different group. The gene discussed is CCL3; the disease is lung cancer.