A meta-analysis published in 2021 that evaluated the results of 25 studies confirmed that although there was no significant association between the levels of adiponectin and disease severity, the patients with EMs did exhibit significantly lower levels of adiponectin and significantly higher levels of leptin compared to the concentrations in the control groups (Zhao Z. et al., 2021). Here, ADIPOQ is linked to eosinophilia-myalgia syndrome.