A large number of studies have now demonstrated the correlation between low adiponectin levels and an increased risk of developing estrogen-dependent diseases (including cervical, endometrial, and breast cancers, as well as uterine fibroids) (Gelsomino et al., 2019; Strzałkowska et al., 2021). The gene discussed is ADIPOQ; the disease is uterine corpus leiomyoma.