Relatively few studies have investigated the role of adiponectin in the pathogenesis of EMs at the clinical and cellular levels, although most have confirmed that adiponectin is an important participant in many biological processes, including apoptosis, autophagy, angiogenesis, inflammatory responses, fibrosis, energy metabolism, and estrogen-mediated effects, and an important correlation has been shown between many factors and their related pathways and the pathogenesis of EMs (Figure 3). This evidence concerns the gene ADIPOQ and eosinophilia-myalgia syndrome.