SHBG can bind to estrogen in the plasma and directly regulate the bioavailability of estrogen and its access to target cells (Fortunati et al., 2010), whereas increased insulin resistance leads to inhibition of SHBG expression, which in turn leads to an increase in the concentration of biologically active estrogen (Hammond et al., 2008; Caselli, 2014; Winters et al., 2014). This evidence concerns the gene SHBG and Insulin resistance.