However, several other studies have shown that adiponectin can enhance angiogenesis by upregulating the expression of pro-angiogenic factors in human umbilical vein endothelial cells (HUVECs) and human microvascular endothelial cells (HMECs) (Adya et al., 2012; Nigro et al., 2021), and it has been shown to promote angiogenesis in chondrosarcoma (Lee et al., 2015), invasive colon cancer (Cai et al., 2016), and ovarian cancer (Ouh et al., 2019), possibly via the regulation of CXC motif chemokine ligand 1 (CXCL1), VEGF, and AMPK. This evidence concerns the gene ADIPOQ and malignant colon neoplasm.