For example, in a mouse model of sepsis, adiponectin has been shown to inhibit lipopolysaccharide (LPS)-induced cardiomyocyte apoptosis by downregulating connexin 43 (Cx43) expression and activating the PI3K/AKT signaling pathway to protect myocardial function (Liu et al., 2021). This evidence concerns the gene GJA1 and Sepsis.