ADIPOQ and eosinophilia-myalgia syndrome: In addition, another group discovered that two polymorphisms in the adiponectin gene, rs2241766 and rs1501299, were associated with EMs susceptibility among women of childbearing age in Henan Province, China, and that the G mutation in the rs2241766 locus may affect splicing and modification of gene expression, resulting in the promotion of adiponectin secretion, which, in turn, induces AMPK phosphorylation and regulates its downstream pathway, thereby protecting against the development of EMs (Zhang et al., 2021).