Adiponectin has been shown to decrease the expression of both cyclin D1 in the human endometrial adenocarcinoma cell lines HEC-1-A and KLE and cyclin E2 in the RL95-2 cell line by activating the AMPK signaling pathway, which led to the blockage of the cell cycle to inhibit the proliferation of cancer cells (Cong et al., 2007; Moon et al., 2011). The gene discussed is ADIPOQ; the disease is cancer.