In the human breast cancer cell line MDA-MB-231, adiponectin was shown to inhibit cell growth by significantly reducing the expression of both cyclin D1 protein and the anti-apoptotic gene Bcl2, while simultaneously upregulating the expression of the pro-apoptotic genes p53 and Bax (Dos Santos et al., 2008; Delort et al., 2012). The gene discussed is ADIPOQ; the disease is breast cancer.