Low adiponectin levels are present in female patients with uterine fibroids, and adiponectin may inhibit smooth muscle tumor growth by lowering estrogen levels through the inhibition of the E2/ERα and insulin-like growth factor 1/insulin-like growth factor 1 receptor pathways (Strzałkowska et al., 2021). The gene discussed is ADIPOQ; the disease is uterine corpus leiomyoma.