Akt is a major protein kinase that exists downstream of PI3K and regulates the expression of various proteins associated with both cellular proliferation and apoptosis (Cinar et al., 2009; Revathidevi and Munirajan, 2019), and a recent study demonstrated that PI3K expression increases and Akt phosphorylation levels become elevated in the eutopic and ectopic endometrium of patients with EMs compared to the levels in healthy controls, indicating that the PI3K/Akt signaling pathway may play an active role in facilitating the establishment of ectopic endometrial tissue (Madanes et al., 2020). The gene discussed is AKT1; the disease is eosinophilia-myalgia syndrome.