ADIPOQ and pancreatic insulinoma: However, a small number of studies have reported contradictory findings; for example, one group showed that adiponectin inhibits SOD activity and promotes ROS secretion in rat RINm insulinoma cells, but without reaching pathological concentrations (Chetboun et al., 2012), and others have reported that full-length adiponectin inhibits ROS production in human phagocytes, whereas globular adiponectin exerts the opposite effect (Chedid et al., 2012).