For example, Qiang Zhang et al. found that the active metabolite of Radix Bupleuri, β-sitosterol, reduced lipid accretion in hepatocytes processing free aliphatic acids by activating the PPARγ-UCP-1 pathway, thus exerting anti-hepatic fibrosis effects (Zhang Y. et al., 2022). The gene discussed is PPARG; the disease is Hepatic fibrosis.