HMGCR and breast cancer: miR-195 targets de novo lipogenesis genes, a hallmark in cancer cells especially in aggressive tumors, and that are related to the production of cell membranes for rapid cell proliferation through action on overexpressed target genes in breast cancer such as BCL-2, FASN, ACACA, and HMGCR (Singh et al., 2015; Chen et al., 2022).