The important role of high expression/depletion of the cellular glycoprotein CD36 and its free form sCD36 in peripheral blood and dysfunction of CD36 in the hypothalamic region of the brain (Le Foll et al., 2015), which is associated with taste sensitivity (Li et al., 2022b, p. 36) in the development of obesity, hyperinsulinism and metabolic syndrome (Karunakaran et al., 2021) has been demonstrated (Le Foll, 2019). The gene discussed is CD36; the disease is hyperinsulinism.