PHB1 and obesity due to melanocortin 4 receptor deficiency: Potentially, peptides that interact with cell receptors can be used to deliver specialized molecules that neutralize the transport function of the PHB/ANX2/CD36 complex and redirect signals in white adipose tissue, hepatocytes and other cells for the treatment of obesity, hepatosteatosis, type 2 diabetes mellitus and metabolic disorders (Rupert and Kolonin, 2022).