TP53 and obesity due to melanocortin 4 receptor deficiency: In obesity and components of the metabolic syndrome (NAFLD) (Bonnet et al., 2022), p53 expression (and activation of the canonical pathway) increases in cells, associated with the aging process of adipocytes and the development of insulin resistance (Franck et al., 2013; Kastenhuber and Lowe, 2017; Krstic et al., 2018).