By interacting with the E3 ligase of Gli1, PHF19 impedes Gli1 ubiquitination, thereby stabilizing and enhancing Gli1 accumulation The ablation of PHF19 in an HCC mouse model significantly hampers tumorigenesis and prolongs survival, underscoring PHF19’s function as a facilitator of Hedgehog pathway activation (Xiaoyun et al., 2021). Here, GLI1 is linked to hepatocellular carcinoma.