For oncogenesis, proteins such as PHF1, PHF6, PHF8, PHF14, PHF19 and PHF20 contribute to cancer progression by modulating key signaling pathways including Wnt, Bai1-Mdm2-P53, NF-κB, HER2, TGFβ, androgen receptor and AKT, influence gene networks crucial for cell proliferation (Maina et al., 2016; Hofvander et al., 2020; Liu et al., 2020; Zhao et al., 2020; Moubarak et al., 2022; Yuan et al., 2022; Hou et al., 2023). The gene discussed is PHF6; the disease is cancer.