PHF5A and neoplasm: Similarly, by interacting with RNA polymerase associated factor PAF1, increased expression of PHF5A correlates with enhanced proliferation and migration in various tumor cell types, including pancreatic tumor (Karmakar et al., 2020), lung cancer (Mao et al., 2019), non-small cell lung cancer (Yang et al., 2022), and colorectal cancer (Wang et al., 2019).