Frequencies of LA, aCL IgG, aβ2GPI IgG, aβ2GPI IgM, and aPS/PT IgM were higher in the patients with APS (PAPS and SLE/APS) compared to those with aPL (+) SLE (81.4% vs. 61.5%, p = 0.006; 61.9% vs. 23.1%, p < 0.001; 46.6% vs. 19.2%, p < 0.001; 31.4% vs. 11.5%, p = 0.006; and 55.9% vs. 38.5%, p = 0.036, respectively). This evidence concerns the gene CD40LG and systemic lupus erythematosus.