F8 and hemophilia A: Two real-world studies [34,71] also reported data for people with mild or moderate hemophilia A. ATHN 7, a natural history cohort study of the safety, effectiveness, and practice of treatment for people with hemophilia, included 38 people with mild or moderate hemophilia A treated with emicizumab; 6 of these individuals had inhibitors against FVIII [34].