According to the multivariate binary logistic regression analysis performed to determine the factors that increase the risk of amyloidosis in FMF patients, age, gender, fibrinogen, ESR, CRP, NLR, RDW, and the presence of arthralgia/arthritis variables, which were found to be clinically and/or statistically significant, were included in the model, while the ESR, male gender, and the presence of arthralgia/arthritis variables remained significant in the model (Table 5). The gene discussed is ESR1; the disease is Arthralgia.