ALB and amyotrophic lateral sclerosis: Considering the influence of sex in CSF profiles, we stratified ALS patients according to sex and found that in male ALS patients, CSF IgG and albumin were correlated with survival status, and CSF IgGindex was negatively correlated with ALSFRS-R (r = −0.109, p = 0.012, Table 2), but these associations did not exist in female ALS.