FNDC5 and Prader-Willi syndrome: These might be found among several factors recognized as specific for PWS compared to EOB, including abundance, distribution, and type of FM, the elevation of adiponectin and ghrelin and reduction of oxytocin and irisin levels, GHD, and impairment in the autonomic nervous system, all of which have been demonstrated to exert some effects on lipid metabolism (such as lysoPcs/PCs, NEFA, HDL-C, etc) (6–12).