Parisi et al.’s (2016) study highlighted how miR-125b in microglia affects NF-κB signaling in ALS, uncovering a detrimental mechanism where miR-125b suppression leads to overactive NF-κB and consequent motor neuron damage. They found that inhibiting miR-125b can improve motor neuron survival, suggesting a new therapeutic approach for ALS (Parisi et al., 2016). Here, NFKB1 is linked to amyotrophic lateral sclerosis.