EFEMP2 and cancer: Indeed, tumors can take advantage of the integrin-facilitated biological communication to take part in every stage of cancer progression, including tumor initiation, proliferation, and invasiveness.45 In particular, while the MSN gene encodes an Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane, EFEMP2 was reported to be associated with the expression of matrix metalloproteinases (MMPs),46 another group of proteins crucial in tissue remodeling.