PSMB2 and central nervous system cancer: For instance, PSMB2 and BCL9L are known to be involved in the Wnt pathway, which activation was verified to increase the stemness of glioma cells.59 Conversely, FBXO42 not only participates in ubiquitination and degradation of p53/TP53, but it was also shown as a critical regulator of the Notch pathway via modulation of RBPJ-dependent global chromatin landscape changes in leukemia.60 It would be of great importance to further research the function of FBXO42 in glioma because it was only reported in other types of cancer.