GNAO1 and neoplasm: Moreover, as a result of the EGFR gene amplification typically present in IDH-wt GBM, EGFR is frequently overactivated in this type, which thus correlates with increased proliferation, apoptosis resistance, and migration of tumor cells.43 A set of other selected features, including MSN, EFEMP2 GNAO1, TOM1L1, FES, FGFRL1, and TMEM106A, was also reported to participate in RTK signaling pathways.