For instance, some of the features that revealed to have the greatest influence in the distinction of GBM were the genes KIAA0495, FBXO17, C9orf64, MSN and ARSD and the methylated sites cg18222083 (TMEM106A), cg05211768 (FES), cg17105609 and cg05866411 (FGFRL1), and cg15603424 (ARNTL), all reported in glioma studies with the exception of the genes ARSD and TMEM106A, which were only reported in other types of cancer. This evidence concerns the gene FGFRL1 and central nervous system cancer.