TP53 and central nervous system cancer: In fact, KIAA0495 has been suggested to modulate cellular apoptosis by regulation of p53-dependent antiapoptotic genes and to promote brain glioma proliferation and invasion, being associated with worse patients’ prognosis.41 Other selected features including XKR8, EMP3, and GNAO1 also showed to be involved in the apoptosis process, but only the role of EMP3 was already elucidated in glioma.