Moreover, as a result of the EGFR gene amplification typically present in IDH-wt GBM, EGFR is frequently overactivated in this type, which thus correlates with increased proliferation, apoptosis resistance, and migration of tumor cells.43 A set of other selected features, including MSN, EFEMP2 GNAO1, TOM1L1, FES, FGFRL1, and TMEM106A, was also reported to participate in RTK signaling pathways. This evidence concerns the gene EFEMP2 and glioblastoma.