From the selected features that distinguish oligodendroglioma, with downregulated gene expression and higher level of methylation compared to the other types, one should note that most are related either with ubiquitination processes (LRRC41, FBXO42, and PSMB2), RNA-binding activity, especially mRNA processing and splicing (CSDE1, SFRS4, PPP1R8, GPBP1L1, THRAP3, SNAPC2, and NANOS1) or signaling (LRRC41, PSMB2, PPP1R8, DRG2, GPR156, KCND2, BCL9L, PLCG1, MAPKAP1, and FGFR2). The gene discussed is PLCG1; the disease is oligodendroglioma.