ARSD and amyloidosis: For instance, ARSD that encodes the protein arylsulfatase D, essentially involved in sphingolipid, estrogen, and protein metabolism, only gained attention recently for its role in amyloidosis.49 Given that amyloid build-up is a part of the glioma tumor environment, and it was inclusively indicated as a potential target for developing a novel class of antitumor drugs,50 more investigation should be dedicated to ARSD gene, whose function was never described in glioma.