IGHE and asthma: Asthma with a type 2 (T2) endotype is driven by alarmins, IL-25, IL-33, and thymic stromal lymphopoetin (TSLP) either through naïve T-cells or through ILC2 cells, and involves the cytokines IL-4, IL-5 and IL-13, as well as eosinophils and, sometimes, IgE (9).