For example, the contributions of a genetic predisposition to Alzheimer’s disease (i.e., presence of the apolipoprotein E epsilon4 allele, the major genetic risk factor) to the various metrics were not considered.92, 395 Further, an emerging literature showing a relationship between liver pathology—including alcohol-related liver disease—and Alzheimer’s disease was not explored.396–398. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.