Other work from our group has also correlated the induction of genes involved in production of ROS, respiration, and mitochondrial biogenesis to increased caspase 9 and caspase 3/7 activation during Salmonella infection (Shah et al., 2014), while caspase 8 and caspase 9 activity have been shown to increase in response to excess ROS (Fink and Cookson, 2007; Man et al., 2013; Shah et al., 2014; Hefele et al., 2018). Here, CASP8 is linked to Salmonella Infections.