Patients with acromegaly experience chronically impaired well-b eing despite biochemical control of GH and IGF-I .24 The factors contributing to this are not completely delineated; however, persistent headaches, joint pain, hypopituitarism, and the long-term medications used to maintain remission, along with the medicalisation that occurs in parallel, are likely contributors. The gene discussed is IGF1; the disease is acromegaly.