LEP and obesity due to melanocortin 4 receptor deficiency: 1. Leptin production is under the control of the obesity gene. It is an adipokine entirely produced in the adipocytes, with the fundamental function of controlling appetite and regulating food intake and energy expenditure.2. Leptin negatively interferes with the regenerative capacity of PDL cells, suggesting leptin as a pathomechanistic link between obesity and compromised periodontal healing