1. Higher expression of visfatin is observed in patients with gingivitis and periodontitis.2. Visfatin and IL-6 levels might play a role in the pathogenesis of periodontal disease and can be used as reliable markers for monitoring the course of periodontitis.3. Visfatin may accelerate periodontal inflammation and bone destruction via the production of MMP-1 and CCL2. This evidence concerns the gene IL6 and periodontal disorder.