An interim analysis including results of the first 48 weeks of treatment has been recently reported, providing the first data relating to the long-term persistence of acromegaly control with OOC beyond 13 months.21 The biochemical response was defined similarly to the CHIASMA OPTIMAL trial (IGF-1 ≤1.0 x ULN based on the average of two assessments at weeks 46 and 48). Here, IGF1 is linked to acromegaly.