SLC5A2 and orthostatic hypotension: Similar findings have been attributed to SGLT-2 inhibitors due to glycosuria.11 Mild volume depletion (presented with polyuria, dehydration, dizziness, vertigo, presyncope, thirst and, rarely, orthostatic hypotension), weight loss, reduction in SBP and elevation of serum creatinine concentration can also be attributed to the pharmacology of the SGLT2 inhibitors class, which cause osmotic diuresis, natriuresis and caloric wasting.11,49