ADM and tuberculosis: ADM is a negative regulator of MUC1 gene expression in trophoblastic cells.88 However, due to the hypoxia caused by vascular alterations in the placenta, MUC1 overexpression has been described.89 The role of ADM in early gestation has also been studied, suggesting that it regulates the optimal expression of MUC1 to promote implantation and facilitate TB invasion.90