While periodontal homeostasis is maintained via proinflammatory [i.e. interleukin 1 beta (IL-1β)] and antiinflammatory (i.e. IL-10) cytokine balance, any destabilization beneficial for the proinflammatory cytokines results in periodontal disease, tissue destruction, and/or impaired healing [12,13]. This evidence concerns the gene IL1B and periodontal disorder.