The phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (AKT) pathway plays a crucial role in the growth, proliferation and metabolic homeostasis of insulin‐sensitive tissues, including AT, liver, and pancreas, and dysregulation of this signaling pathway leads to the development of obesity and T2D.223, 224, 225. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.