Studies using mouse models have demonstrated that diet‐induced obesity leads to adipose‐resident ILC1 accumulation via IL‐12 production, drives M1‐like macrophage polarization through targeted cytotoxicity and induces obesity‐associated IR through IFN‐γ secretion.95, 96. The gene discussed is IFNG; the disease is obesity due to melanocortin 4 receptor deficiency.