ALPI and inflammatory bowel disease: ,46 Indeed, among the cytokines used in our study, IFNγ seemed to have the major contributing effect in the upregulation of IAP, FABP6, and PIGR. Although used at a low dose, it is striking to observe that cytokine mix and IFNγ alone induced maturation of the epithelial cells in terms of brush border enzymes expression and barrier formation, rather than damaging of the intestinal epithelial barrier as it is described in specific pathologic conditions such as IBD.47