Based on this study, it can be concluded that the effect of gotu kola extract (Centella asiatica) in improving the sleep activity of zebrafish larvae (Danio rerio) insomnia model by extending the total inactivity time (cumulative duration) and shortening the duration of the first time of sleep (latency to first sleep) in light and dark phases through inhibition of orexin, ERK, p38 and Akt. The gene discussed is HCRT; the disease is insomnia measurement.