Elevated MDSC is reported in AR, AS, and other allergic diseases, but MDSC expression is also elevated in healthy individuals after exposure to allergens, suggesting the possibility that MDSCs may have both inhibitory and pro-validating roles, and that the roles of different phenotypes of MDSCs and chemokines may be the key factors influencing the function of MDSCs (54).Our research only found that one MDSC phenotype has a protective effect against AAD (CD14 on Mo MDSC, pIVW-AR = 0.025, betaAR = -0.032, ORAR = 0.968). This evidence concerns the gene CD14 and allergic disease.