Different subtypes of Transitional B cells also have different functions, for example, the T2/T3 type produces IL-10 to reduce CD4+ T-cell proliferation but, in some autoimmune diseases, Trb also secretes anti-inflammatory factors (IL-6 and TNF-α) that disrupt the Treg/Th17 balance (49, 50). The gene discussed is TNF; the disease is autoimmune disease.