In line with these findings, the analysis of tumor-infiltrating lymphocyte (TIL) population also revealed that both CD4+ and CD8+ T-cell accumulation was significantly elevated in tumor tissues after treatment with HY-oAd monotherapy or its combination with 9-ING-41 in comparison with the PBS control group with extremely low-level T-cell infiltration (less than 5% of total tumor cell population was either CD4+ or CD8+ T cells; ***p < 0.001; Figure 6B). This evidence concerns the gene CD4 and neoplasm.