Specifically, this study revealed that the TAM markers chemokine ligand (CCL)-2, CD68 and interleukin 10 (IL10) are strongly correlated with CHSY3 in STAD, as are interferon regulatory factor 5 (IRF5) and prostaglandin-endoperoxide synthase 2 (PTGS2) in the M1 phenotype and with CD163, V-Set and immunoglobulin domain containing 4 (VSIG4), and the Membrane Spanning 4-Domains A4A (MS4A4A) in the M2 phenotype (p < 0.001; Figure 5C; Supplementary Table 1). Here, IRF5 is linked to gastric adenocarcinoma.