VEGFA and posterior cortical atrophy: In addition, after ADT, not only does vascular endothelial growth factor decrease with the decrease of androgen level, but also the BF of PCa tissues decreases, and cells show obvious apoptosis and necrosis, thus achieving anti-tumor angiogenesis, so Ktrans, Kep, and Ve values are significantly reduced after endocrine therapy (Kim et al., 2021; Ueda et al., 2022).