MFN1 and hydrops fetalis: Yue and colleagues [370] found that prolonged activated Yes-associated protein 1 disrupted mitochondrial dynamics and triggered mitochondrial dysfunction by targeting Dnm1l and MFN1 in a mouse model of abdominal aortic constriction-induced HF, resulting in cardiac hypertrophy, and this process was also related to impaired mitochondrial biogenesis.