OPA1 and chronic obstructive pulmonary disease: In COPD patients exposed to cigarette smoke, alveolar epithelial cells or fibroblasts partially modulate MQC in response to external stimuli by regulating the coexistence ratio of different forms of OPA1, namely L-OPA1, and S-OPA1, and under the intervention of OPA1-interacting protein SLP-2, thereby mitigating damage [569].