In non-small cell lung cancer (NSCLC) cells, lactate downregulated glycolytic enzymes hexokinase 1 (HK-1) and pyruvate kinase (PKM) while upregulating tricarboxylic acid cycle enzymes succinate dehydrogenase A (SDHA) and isocitrate dehydrogenase 3γ (IDH3G) mRNA levels [71]. Here, PKM is linked to non-small cell lung carcinoma.