ROCK1 and cardiovascular disorder: Recently, several downstream target genes of GAS5 have been identified in diverse cardiovascular diseases, including CALM2 and PDCD4 in myocardial infarction [17, 23], TXNIP in coronary atherosclerosis [18], CYP11B2 in diabetic cardiomyopathy [24], P2Y12 in coronary artery disease [25], and ROCK1 in myocardial ischaemia/reperfusion injury [26].