To delve deeper into the mechanism, we performed reduced GSH quantification assays in AML cells, following treatment by liposome-MAL, oridonin, orid-liposome, orid-liposome-MAL, TLR2 pep-orid-liposome 1:1 and TLR2 pep-orid-liposome 5:1. The gene discussed is TLR2; the disease is acute myeloid leukemia.