Recent research has suggested a close association between the GPX4-GSH system, arterial atherosclerosis, and vascular calcification, potentially linked to the phenotypic transformation of VSMCs and Fer-1,ferroptosis inhibitor, is effective in mitigating vascular calcification, while ferroptosis-inducing drug erastin can significantly accelerate calcification in the aortic ring [21, 22, 36, 37]. This evidence concerns the gene GPX4 and atherosclerosis.