Targeted analyses of nuclear factor erythroid-related factor 2 (Nrf2), a transcription factor that regulates expression of anti-oxidant genes, revealed greater downregulation among patients with endotype A. More recently among children with septic shock in secondary analyses of the Coagulation and Fibrinolysis in Pediatric Insulin Titration (CAF-PINT) study, Yang et al. identified two septic shock subclasses using bulk mRNA sequencing 25. Here, NFE2L2 is linked to septic shock.