The fusion gene pair in B-ALL detected in the onset samples is illustrated in Fig. 2B. The most frequently detected fusion gene pairs included DHRSX-DHRSX (n = 12), ETV6-RUNX1 (n = 8), C008696-AC008696 (n = 8), CXorf21-MROS18A (n = 7), AL591378-DMD (n = 6), VRK3-VRK3 (n = 5), KLF2-SENP3-EIF4A1 (n = 5), MRPL13-ZNF740 (n = 5), AC016876-KLF2 (n = 5), EIF4A1-KLF2 (n = 5), AGO2-ST3GAL1 (n = 4), and CYB5A-DIPK1C (n = 4). The gene discussed is CYB5A; the disease is acute lymphoblastic leukemia.