In a previous study, according to the transcriptional landscape, B-ALL patients were divided into subgroups with different fusion genes and known gene mutations, which included MEF2D fusions, TCF3-PBX1, ETV6::RUNX1 or ETV6::RUNX1-like, DUX4 fusions, ZNF384 fusions, BCR::ABL1 or BCR::ABL1-like, high hyperdiploidy, KMT2A fusions, PAX5 and CRLF2 fusions, PAX5 (p. P80R) mutations, IKZF1 (p. N159Y) mutations, ZEB2 (p. H1038R)/IGH::CEBPE, TCF3/4::HLF, and NUTM1 fusions [3]. Here, HLF is linked to acute lymphoblastic leukemia.