Diagnosing sepsis-induced coagulopathy, like trauma-induced coagulopathy (TIC), has undergone major developments in the last 10 years as whole blood viscoelastic methods have replaced the older unreliable plasmatic methods of prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) [14, 46–48]. This evidence concerns the gene F2 and blood coagulation disease.