The synergistic direct antitumor effect was achieved by recruiting and activating DCs through 3M-052, enhancing the ICD induction of BET inhibitor, mediating intratumoral infiltration of TILs (such as CD8+ T cells), reshaping the tumor immune microenvironment and activating antitumor immune responses, thereby suppressing the malignant behavior of TNBC. Here, DNER is linked to neoplasm.